Our uniqueness makes us special, makes perception valuable - but it can also make us lonely. This loneliness is different from being 'alone': You can be lonely even surrounded by people. The feeling I'm talking about stems from the sense that we can never fully share the truth of who we are. I experienced this acutely at an early age.
Nothing in this world can take the place of persistence. Talent will not: nothing is more common than unsuccessful men with talent. Genius will not; unrewarded genius is almost a proverb. Education will not: the world is full of educated derelicts. Persistence and determination alone are omnipotent.