I would finally renounce my delusional hypotheses and revert to thinking of myself as a human of more conventional circumstances and return to mathematical research. John Forbes Nash, Jr.
So far as hypotheses are concerned, let no one expect anything certain from astronomy, which cannot furnish it, lest he accept as the truth ideas conceived for another purpose, and depart from this study a greater fool than when he entered it. Nicolaus Copernicus
The grand aim of all science is to cover the greatest number of empirical facts by logical deduction from the smallest number of hypotheses or axioms. Albert Einstein
True science is never speculative; it employs hypotheses as suggesting points for inquiry, but it never adopts the hypotheses as though they were demonstrated propositions. Cleveland Abbe
Research is so unpredictable. There are periods when nothing works and all your experiments are a disaster and all your hypotheses are wrong. Francis Collins