This is largely the methodology I've used throughout my career - that is, starting with a question as to what might be the properties of a set of compounds that could be invented which were unusual and unpredictable. Many times I've felt a bit like Columbus setting sail.
Donald Cram

To go out with the setting sun on an empty beach is to truly embrace your solitude.
Jeanne Moreau

To me, if a heterosexual has a right to do it, then I have a right to do it. And if it's important to the gay youth - who are now setting the agenda - then its important to me.
Harvey Fierstein

Under pressure, people admit to murder, setting fire to the village church or robbing a bank, but never to being bores.
Elsa Maxwell

We can identify with Frodo and Sam, setting off not knowing quite where they are going and what they are to do.
Timothy Radcliffe

We have an electronic vein we have tapped and applied it to a rock setting like tons of bands out there.
Mike Lowry

We meet before the movie and she gives you charts with sounds on them and makes a tape of examples. While they are setting up the scene, I go with her to the trailer and we go through the scene and correct the speech.
Albert Finney

We should see the leadership from the White House setting dates certain for certain goals of achieving greater alliance on alternative and renewable energy sources, but we are not.
Ron Kind

We've always been the development project that lived in a time pressured setting and always where commercial entities were relying heavily on releases in a certain time frame.
Mitchell Baker

We've got to recognize that when we march into Iraq, we're setting up the card tables in front of every university in the Arab world, the Islamic world, to recruit for al-Qaida.
Chris Matthews

What a couple. I'm consumed into ashes. And he's always raking up the ashes and setting them on fire again.
Agnes Smedley

When it comes to setting national priorities, determining threats, defining challenges, and fashioning and implementing foreign and defense policies, the United States and Europe have parted ways.
Robert Kagan

When the government picked companies and gave them monopoly rights to frequencies in San Francisco and Los Angeles and New York and Chicago, it was picking the winners of the competition; it wasn't setting the terms of the competition.
Robert McChesney

When you're doing a deal with someone in the southern Sahara, it's a very different way of doing business than in London. You can't sign them in the usual way because they'd end up getting ripped off, which would defeat the object of setting up a label like this.
Damon Albarn

Whence it follows that God is absolutely perfect, since perfection is nothing but magnitude of positive reality, in the strict sense, setting aside the limits or bounds in things which are limited.
Gottfried Leibniz

Who ever hears of fat men heading a riot, or herding together in turbulent mobs? No - no, your lean, hungry men who are continually worrying society, and setting the whole community by the ears.
Washington Irving

With Cold Sassy Tree having its first production, I saw no necessity to do anything other than produce it with the correct setting.
Bruce Beresford

Women have not yet realized the cowardice that resides, for if they should decide to do so, they would be able to fight you until death; and to prove that I speak the truth, amongst so many women, I will be the first to act, setting an example for them to follow.
Veronica Franco

You can become an even more excellent person by constantly setting higher and higher standards for yourself and then by doing everything possible to live up to those standards.
Brian Tracy

You can't substitute promise after promise with known violators of prior promises at the expense of protecting ourselves or setting an example.
Fred Thompson