Our chief justices have probably had more profound and lasting influence on their times and on the direction of the nation than most presidents.
Richard M. Nixon

Our country, like every modern state, needs profound democratic reforms. It needs political and ideological pluralism, a mixed economy and protection of human rights and the opening up of society.
Andrei Sakharov

Our observation of nature must be diligent, our reflection profound, and our experiments exact. We rarely see these three means combined; and for this reason, creative geniuses are not common.
Denis Diderot

Please let me assure you, however, that the keen disappointment and regret which I feel in this regard serve only to enhance my profound appreciation of the great honor which you have done me; and my sincere gratitude for your generous action.
Cordell Hull

Real nobility is based on scorn, courage, and profound indifference.
Albert Camus

Sometimes a concept is baffling not because it is profound but because it is wrong.
E. O. Wilson

That profound night freedom was agreeable and exciting.
Carmen Laforet

That the primary effect of gene mutation may be as simple as the substitution of a single amino acid by another and may lead to profound secondary changes in protein structure and properties has recently been strongly indicated by the work of Ingram on hemoglobin.
Edward Lawrie Tatum

That was when I realised that music is the most profound, magical form of communication there is.
Lesley Garrett

That's the way it is with poetry: When it is incomprehensible it seems profound, and when you understand it, it is only ridiculous.
Galway Kinnell

The arrogance of the artist is a very profound thing, and it fortifies you.
James A. Michener

The cosmical importance of this conclusion is profound and the possibilities it opens for the future very remarkable, greater in fact than any suggested before by science in the whole history of the human race.
Francis William Aston

The country has undergone a profound social upheaval, the greatest the proletariat has ever known.
C. L. R. James

The first, that their pretensions to this possession of an art properly so called in their art of speaking are entirely unfounded; and the second, that they are involved in a profound mistake in their confusion of the good with the pleasant.
Friedrich Schleiermacher

The Holy Bible is an abyss. It is impossible to explain how profound it is, impossible to explain how simple it is.
Ernest Hello

The man who is aware of himself is henceforward independent; and he is never bored, and life is only too short, and he is steeped through and through with a profound yet temperate happiness.
Richard M. Nixon

The most profound statements are often said in silence.
Lynn Johnston

The most profound things are inexpressible.
Jenny Holzer

The most profound, tangible influence in my life has been my wife, Monique. I don't know that I would even be alive were it not for her, and I certainly would not be the person that I am today.
Edgar Winter

The most striking development of the great depression of 1929 is a profound skepticism of the future of contemporary society among large sections of the American people.
C. L. R. James