A key issue in developmental biology at that time was the problem of how cells underwent differentiation, with most workers concentrating on explanations in terms of changes in enzyme and gene regulation.
Paul Nurse
As has repeatedly been stated, the underlying hypothesis, which in a number of cases has been supported by direct experimental evidence, is that each gene controls the production, function, and specificity of a particular enzyme.
Edward Lawrie Tatum
During my early years at Minnesota I conducted an evening enzyme seminar.
Paul D. Boyer
These studies resulted eventually in a complete sequence analysis of the complex from several species, and in the atomic resolution structure of the F catalytic domain of the enzyme from bovine mitochondria, giving new insights into how ATP is made in the biological world.
John E. Walker
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